In the episode 2.11 Dean and Sam travel to Connecticut, where two mysterious deaths have been reported. The spirit of a girl who died years ago inhabited the house, killing those who hoped to sell it. She was tied closely to the family’s history, and with a little digging they find that the owner’s grandmother had been working to repress the spirit for years: It was her younger sister, wanting keep things the same as they’d always been, hurt and angry over being shunned.
Inns were popular places back in New England, with its long history in the country. Go to any number of locations around New England and you’ll likely find a story here or there about a guest murdered or otherwise deceased, with their spiritual remains still around somewhere.